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As mentioned previously, injection ofcAMP into effector T cells induces T cell paralysis through the activation of the cAMP PKApathway, which interfere with T cell proliferative pathways related to NFATc1 productionand a myriad of other translational pathways that lead to T cell proliferation (Bodor 2012).Resting Tregs, unlike effector T cells are full of cAMP and to a certain extent, it contributesto the Tregs ?state of anergy? for the very same reasons it leads to anergy in responding Tcells when they are injected with it.

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Comparing the unadjusted and adjusted estimates gives an indica-tion of whether or not the factors were important confounders.

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